Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression

This lecture from the iBioSeminars project is presented by Mary C. Berckerle from the Huntsman Cancer Institute at the University of Utah and covers the identification of the focal adhesion protein, zyxin, by a lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed. This video is the second of three parts, running 50:54 minutes and can be downloaded in QuickTime, MP4, M4V, or PDF formats and with subtitles. The video can also be streamed through YouTube or iTunes U.