BioMEMS Applications Learning Module

Module Description:

This learning module, from Support Center for Microsystems Education (SCME), covers major developments and applications of biological microelectromechanical systems (BioMEMS). "There are three activities included that provide further exploration of these applications, how they are used and how they work." The activities deal with the use of nanoparticles as machines, the use of biomolecules and micro-size devices for medical diagnostics, and the use of BioMEMS in the fields of genetics and diagnostics.

Module Contents:

The module includes seven instructor guides, six participant guides, and two PowerPoint presentations. PDF and DOC versions are provided for each resource. The included instructor and participant guides are Primary Knowledge (PK) Guide, Knowledge Probe, Assessment, DNA Hybridization Activity, Nanomachines Activity, and ELISA Activity. Instructor guides include additional content such as instructor notes and questions and answers. A Learning Module Map (LM) Instructor Guide is also included. 

The LM map provides information about the module including module contents, target audience, and a map that is divided into the following three sections: Important Steps, Key Points, and Reasons. 

The Knowledge Probe includes ten questions that assess a participant's knowledge of BioMEMS applications. A final assessment document with ten questions is also included.

The Primary Knowledge (PK) unit guide "provides an overview of the biomedical applications of MicroElectroMechanical Systems (MEMS)." This unit includes the following learning objectives:

• Summarize at least three (3) areas of applications for BioMEMS devices. 
• Describe specific examples within at least three (3) areas of applications for BioMEMS devices.
• Analyze advantages and possible disadvantages of BioMEMS devices.

The following sections are included in this unit guide: Description and Estimated Time to Complete, Introduction, Objectives, Key Terms, The State of BioMEMS, BioMEMS Sensors Placement, Externally Connected Sensors, Implanted Devices, Glucometers, and more. 

The module includes three activities that provide the opportunity to explore biomedical applications of MEMS. The Nanomachines activity includes the following objectives:

• Interact with nanomachines using Molecular Workbench
• Explain the forces that allow nanomachines to work
• Demonstrate your understanding of these forces by designing and building a nanomachine

The DNA Hybridization activity includes the following objectives:

• Demonstrate your understanding of how probes made of nucleotide sequences can bind to complementary target DNA sequences.
• State at least two bioMEMS applications that study or utilize DNA hybridization.

The ELISA activity includes the following objectives: 

• Explain the antibody/antigen ELISA process.
• Correctly demonstrate connecting the enzymatic reaction with amplification of biological signals.

This module also includes two PowerPoint presentations. The BioMEMS Applications Overview presentation includes a unit overview, objectives, a summary and covers topics such as the BioMEMS market, BioMEMS sensor placement, topical sensors, glucometers, and more. A PDF version is also included for the Applications Overview presentation. The BioMEMs and Their Applications presentation covers a number of applications and include slide notes. 

For orientation purposes App_BioMEM_Apps_P1_LM_MAP_IG.pdf is included as a separate attachment and offers a sample of the type of material included in this module.

Below is a list of the files included in the .zip attachment. The size of each file is included in parenthesis. 

BioMEMS Applications (37 files, 16.1 MB)

• Instructors
  • PDFs
    • BioMEMS Applications Activity: Nanomachines Instructor Guide (App_BioMEM_AC14_IG.pdf 135 KB)
    • BioMEMS Applications Activity: ELISA Instructor Guide (App_BioMEM_AC15_IG.pdf 174 KB)
    • BioMEMS Applications Activity: DNA Hybridization Instructor Guide (App_BioMEM_AC16_IG.pdf 335 KB)
    • BioMEMS Applications Overview Learning Module Map (App_BioMEM_Apps_P1_LM_MAP_IG.pdf 117 KB)
    • BioMEMS Applications Overview Assessment Instructor Guide (App_BioMEM_FA14_IG.pdf  122 KB)
    • BioMEMS Applications Overview Knowledge Probe Instructor Guide (App_BioMEM_KP14_IG.pdf 125 KB)
    • BioMEMS Applications Overview Primary Knowledge (PK) Instructor Guide (App_BioMEM_PK14_IG.pdf 1.9 MB)
  • Word Docs
    • BioMEMS Applications Activity: Nanomachines Instructor Guide (App_BioMEM_AC14_IG_September2017.docx 135 KB)
    • BioMEMS Applications Activity: ELISA Instructor Guide (App_BioMEM_AC15_IG_September2017.docx 174 KB)
    • BioMEMS Applications Activity: DNA Hybridization Instructor Guide (App_BioMEM_AC16_IG_September2017.docx 335 KB)
    • BioMEMS Applications Overview Learning Module Map (App_BioMEM_Apps_P1_LM_MAP_IG_September2017.docx 117 KB)
    • BioMEMS Applications Overview Assessment Instructor Guide (App_BioMEM_FA14_IG_September2017.docx 122 KB)
    • BioMEMS Applications Overview Knowledge Probe Instructor Guide (App_BioMEM_KP14_IG_September2017.docx 125 KB)
    • BioMEMS Applications Overview Primary Knowledge (PK) Instructor Guide (App_BioMEM_PK14_IG_September2017.docx 1.9 MB)
• Participants
  • PDFs
    • BioMEMS Applications Activity: Nanomachines Participant Guide (App_BioMEM_AC14_PG.pdf 120 KB)
    • BioMEMS Applications Activity: ELISA Participant Guide (App_BioMEM_AC15_PG.pdf 172 KB)
    • BioMEMS Applications Activity: DNA Hybridization Participant Guide (App_BioMEM_AC16_PG.pdf 323 KB)
    • BioMEMS Applications Overview Assessment Participant Guide (App_BioMEM_FA14_PG.pdf 103 KB)
    • BioMEMS Applications Overview Knowledge Probe Participant Guide (App_BioMEM_P1_KP14_PG.pdf 125 KB)
    • BioMEMS Applications Overview Primary Knowledge (PK) Participant Guide (App_BioMEM_PK14_PG.pdf 1.9 MB)
  • Word Docs
    • BioMEMS Applications Activity: Nanomachines Participant Guide (App_BioMEM_AC14_PG_August2017.docx 44 KB)
    • BioMEMS Applications Activity: ELISA Participant Guide (App_BioMEM_AC15_PG_August2017.docx 73 KB)
    • BioMEMS Applications Activity: DNA Hybridization Participant Guide (App_BioMEM_AC16_PG_August2017.docx 232 KB)
    • BioMEMS Applications Overview Assessment Participant Guide (App_BioMEM_FA14_PG_August2017.docx 42 KB)
    • BioMEMS Applications Overview Knowledge Probe Participant Guide (App_BioMEM_P1_KP14_PG_August2017.docx 44 KB)
    • BioMEMS Applications Overview Primary Knowledge (PK) Participant Guide (App_BioMEM_PK14_PG_August2017.docx 1.1 MB)
• Presentations
  • BioMEMS and Their Applications (BioMEMS_Applications_Overview_narrated.pptx 3.4 MB)
  • BioMEMS Applications Overview (BioMEMS_Applications_Overview.pdf 2.6 MB)
  • BioMEMS Applications Overview (BioMEMS_Applications_Overview.pptx 1.2 MB)